The aim of the present study was to improve the solubility and dissolution rate of a poorly water-soluble drug by a solid dispersion technique, in order to investigate the effect of these polymers on release mechanism from solid dispersions. Telmisartan was used as a model drug to evaluate its release characteristics from different matrices. Solid dispersions were prepared by using polyethylene glycol 6000 (PEG-6000), in different drug-to-carrier ratios (1:2, 1:4, 1:6, 1:8, 1:10). The solid dispersions were prepared by solvent method. The pure drug and solid dispersions were characterized by in-vitro dissolution study. Distilled water was used as dissolution media, 1000 ml of distilled water was used as dissolution medium in each dissolution basket at a temperature of 37°C and a paddle speed of 100 rpm. The very slow dissolution rate was observed for pure telmisartan and the dispersion of the drug in the polymers considerably enhanced the dissolution rate. This can be attributed to improved wettability and dispersibility, as well as decrease of the crystalline and increase of the amorphous fraction of the drug. In this study solvent evaporation technique was used for the preparation of solid dispersion with high drug content, dissolution rate, solubility in PEG 6000 (1:6). From this study it was concluded that solubility and dissolution rate was increased with the ratio of drug:PEG 6000 at 1:6 as compare with pure drug. Solid dispersion containing polymer prepared with solvent method showed significant improvement in the release profile as compared to pure drug, telmisartan.
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